Deferasirox

 
Chemical Formula: C₂₁H₁₅N₃O₄

Molecular Weight: 373.36

CAS Number: 201530-41-8

Description: White to off-white solid, ≥98.0% (HPLC)

Deferasirox is a synthetic, orally bioavailable, achiral, tridentate triazole derived from salicylic acid with iron-chelating activity. Deferasirox chelates iron at a 2:1 (ligand: iron) ratio. Because of its oral availability and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life.

It is used in the management of chronic iron overload due to blood transfusion or non-transfusion dependent thalassemia. Deferasirox has been linked to a low rate of transient serum aminotransferase elevations during therapy and to rare instances of clinically apparent liver injury, which can be severe and even fatal.